As cannabis research
progresses, there is a lot to know about cannabidiol (CBD). And with
the legalization of hemp in the United States, it might be edging out
THC as the most popular cannabinoid among consumers.
CBD has been
lauded as a helpful tool in fighting pain, inflammation, anxiety, and
addiction. And for people who aren’t interested in the intoxicating
qualities of THC, the best part about CBD is that it doesn’t make you
high. That’s because THC and CBD affect the body in different ways.
all comes down to the endocannabinoid system (ECS), and how CBD
interacts with cannabinoid receptors in the body. These receptors reside
on the surfaces of cells, and convey messages coming from endocannabinoids, like anandamide and 2-arachidonoylglycerol (2-AG). Depending on the type of cell, these messages initiate various responses.
Cannabinoid receptors exist throughout our bodies, and the two main types are CB1 and CB2 receptors. CB1 receptors
are mainly found in the nervous system, in the brain, neurons and
spinal cord. These are also found in the digestive tract. CB2 receptors
are largely found in peripheral organs and are associated with the
THC, CBD has a low affinity for binding with cannabinoid receptors.
That may be why it doesn’t produce the same intoxicating high as THC.
CBD modulates the receptors, affecting how they respond to certain
cannabinoids. It also modulates receptors that aren’t cannabinoids, and
it can enhance the effects of endocannabinoids, like anandamide.
For instance, CBD interacts with fatty acid binding proteins (FABP), which transport endocannabinoids. By preventing the breakdown of anandamide,
CBD raises the levels of this endocannabinoid in the brain. That’s one
reason why CBD has the potential to be effective in treating seizures.
It’s in this same way that CBD can also increase levels of adenosine
in the brain. By allowing the accumulation of adenosine, CBD can help
induce sleep, ease anxiety and lower inflammation. But interacting with
FABPs isn’t the only way CBD affects the body. CBD also inhibits fatty acid (FAAH) enzymes, increasing levels of anandamide and 2-AG — which also ease anxiety and calm the mind.
doesn’t just interact with endocannabinoids. It has an effect on a
variety of other signal mechanisms in the body, including
By activating the 5-HT1A
(hydroxytryptamine) receptor, it can work to further ease anxiety. The
5-HT1A is part of a matrix of receptors that respond to serotonin — a
neurotransmitter involved with anxiety, pain, digestion, mood, blood
clotting and appetite. By activating 5-HT1A, CBD can ease anxiety, and
according to this study — published in the journal Pain (2009) — possibly alleviate pain as well.
But that’s not the only receptor CBD interacts with to calm anxiety. In this study, published in Pharmacological Research (2017),
scientists discovered that CBD and 2-AG were both modulators of the
GABA-A receptor. In this way, CBD enhances GABA — which creates an
And what about those cancer-fighting
properties of CBD we’ve heard so much about? They come from CBD’s
ability to activate peroxisome proliferator activated receptors (PPAR).
By serving as an agonist of the PPAR-gamma receptor, it can prevent the progression of cancer. Science has suggested that activating this receptor also promotes a neuroprotective effect.
various interactions with receptors, CBD also confers its famed
anti-inflammatory and pain management effects. CBD binds to TRPV1 receptors,
which play a role in fighting cancer. TRPV is short for “transient
receptor potential cation channel subfamily V,” the “v” stands for
vanilloid. These receptors are protein complexes that control the flow
of ions. Through binding with this receptor, CBD can also affect the perception of pain by reducing sensitivity.
CBD also works to fight pain and inflammation by serving as an antagonist of GPR55.
Through working to block the signaling of this G-protein coupled
receptor, CBD can relieve inflammation and pain. Inhibiting this
receptor also decreases the spread of cancer cells.
trend? Much of what CBD does in the body overlaps among receptors and
signal pathways. CBD’s activation of PPARg receptors also reduces gene expression in inflammation resulting from oxidative stress. It might also help with treating Alzheimer’s disease.
now, scientists are still learning about the ECS and human CBD
receptors. But what we know so far is that the ECS is sensitive to
stimuli. You can feed your ECS
for more balanced health by exercising, consuming plenty of omega-3
fatty acids and reducing stress. Cannabinoids like CBD and THC can also
help in treating conditions that affect this system.
The ongoing research into cannabis is exciting due to its remarkable potential to rebalance the ECS. As science continues examining the clues, we may see an emergence of treatments that target specific receptors, in order to battle disease and illness caused by a malfunctioning ECS. This much is clear, CBD conveys a multitude of therapeutic effects through an array of receptors that we’re only just beginning to understand.
Source: Christine Colbert | https://www.rxleaf.com/human-cbd-receptors/